varenicline ameliorates learning and memory deficits in amyloid β(25–35) rat model of alzheimer’s disease

Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease

Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an ...

Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease

Genistein ameliorates learning and memory deficits in amyloid β(1-40) rat model of Alzheimer's disease.

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Ageing, heredity, and induced oxidative stress are among proposed risk factors. The increased frequency of the disease in women also suggests a role for estrogen in development of AD. In the present study, ef...

Rosmarinic acid mitigates learning and memory disturbances in amyloid β(25–35)-induced model of Alzheimer’s disease in rat

Abstract Background and Objective: Alzheimer’s disease (AD) is a weakening neurodegenerative disorder typified by increased b-amyloid (Ab) deposition and neuronal dysfunction causing to impaired learning and memory. Among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. The aim of this study was to determine the effects of the rosmarinic acid on lear...

GABAA agonist muscimol ameliorates learning/memory deficits in streptozocin-induced Alzheimer’s disease non-transgenic rat model

MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...

Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats

Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...